3-Hydroxykynurenine

3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis[1].

Product Specifications

CAS Number

[484-78-6]

Product Name Alternative

3-Hydroxy-DL-kynurenine

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; Endogenous Metabolite

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/3-hydroxykynurenine.html

Purity

99.90

Solubility

1M HCl : 33.33 mg/mL (ultrasonic; adjust pH to 1 with HCl) |DMSO : 1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)C(N)CC(C1=CC=CC(O)=C1N)=O

Molecular Formula

C10H12N2O4

Molecular Weight

224.21

Precautions

H315, H319, H335

References & Citations

[1]S Okuda, et al. 3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity. J Neurochem. 1998 Jan;70 (1) :299-307.|[2]Sarah S Zaher, et al. 3-hydroxykynurenine suppresses CD4+ T-cell proliferation, induces T-regulatory-cell development, and prolongs corneal allograft survival. Invest Ophthalmol Vis Sci. 2011 Apr 22;52 (5) :2640-8.