L-Glutamic acid (monosodium salt)

L-Glutamic acid monosodium salt is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA) . L-Glutamic acid monosodium salt has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid monosodium salt can be used in the study of neurological diseases. L-Glutamic acid monosodium salt acts at ionotropic and metabotropic glutamate receptors[1][2][3][4][5].

Product Specifications

CAS Number

[142-47-2]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Endogenous Metabolite; Ferroptosis; iGluR

Type

Natural Products

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/L-Glutamic_acid_monosodium_salt.html

Purity

99.42

Solubility

DMSO : < 1 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(O[Na])CC[C@H](N)C(O)=O

Molecular Formula

C5H8NNaO4

Molecular Weight

169.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Liberatore F, et al. Permissive role for mglu1 metabotropic glutamate receptors in excitotoxic retinal degeneration. Neuroscience. 2017 Sep 14. pii: S0306-4522 (17) 30640-1.|[2]Giorguieff MF, et al. Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices. Neurosci Lett. 1977 Oct;6 (1) :73-7.|[3]Boga Pekmezekmek A, et al. L-Glutamic acid monosodium salt reduces the harmful effect of lithium on the development of Xenopus laevis embryos. Environ Sci Pollut Res Int. 2020 Nov;27 (33) :42124-42132.|[4]Croce N, et al. Hydrochloric acid alters the effect of L-glutamic acid on cell viability in human neuroblastoma cell cultures. J Neurosci Methods. 2013 Jul 15;217 (1-2) :26-30.|[5]Salyha N, et al. Protective role of l-glutamic acid and l-cysteine in mitigation the chlorpyrifos-induced oxidative stress in rats. Environ Toxicol Pharmacol. 2018 Dec;64:155-163.