LUF6000

LUF6000 is an orally active allosteric modulator of the A3 adenosine receptor. LUF6000 has potent anti-inflammatory effect[1][2].

Product Specifications

CAS Number

[890087-21-5]

UNSPSC

12352005

Hazard Statement

H302

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/LUF6000.html

Purity

99.09

Solubility

DMSO : 14.29 mg/mL (ultrasonic)

Smiles

ClC1=CC(NC2=NC3=C(C=CC=C3)C4=C2NC(C5CCCCC5)=N4)=CC=C1Cl

Molecular Formula

C22H20Cl2N4

Molecular Weight

411.33

Precautions

P264-P270-P330-P501

References & Citations

[1]Du L, et al. Species differences and mechanism of action of A3 adenosine receptor allosteric modulators. Purinergic Signal. 2018;14 (1) :59-71.|[2]Cohen S, et al. A₃ adenosine receptor allosteric modulator induces an anti-inflammatory effect: in vivo studies and molecular mechanism of action. Mediators Inflamm. 2014;2014:708746.