CXCR4 antibody

C-X-C chemokine receptor type 4 (CXCR4) is a widely expressed G protein-coupled seven-transmembrane receptor. CXCL12/SDF-1 is the biological ligand for CXCR4. The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathways initiating signals related to chemotaxis, cell survival and/or proliferation, increase in intracellular calcium, and gene transcription (PMID: 20484021) . CXCR4 also functions as a coreceptor for HIV-1 entry (PMID: 9427609) . CXCR4 has a calculated molecular weight of 40 kDa. In addition to the predicted species of 45-47 kDa for glycosylated CXCR4 monomers, due to ubiquitination, dimeration, and different degrees of glycosylation, additional species can also exist and have been reported in some researches, including 67 kDa (PMID: 23917520), 55, 67, 87 kDa (PMID: 20028517), 80 kDa (PMID: 10506573), 47, 50, 62, and 98 kDa (PMID: 16204649) .

C-X-C chemokine receptor type 4 (CXC-R4, CXCR-4) |FB22|Fusin|HM89|LCR1|Leukocyte-derived seven transmembrane domain receptor (LESTR) |Lipopolysaccharide-associated protein 3 (LAP-3, LPS-associated protein 3) |NPYRL|Stromal cell-derived factor 1 receptor (SDF-1 receptor) |CXCR4