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Bazedoxifene (Standard)

Bazedoxifene (Standard) is the analytical standard of Bazedoxifene. This product is intended for research and analytical applications. Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[1][2].

Product Specifications

CAS Number

[198481-32-2]

Product Name Alternative

TSE-424 (Standard)

UNSPSC

12352005

Target

Estrogen Receptor/ERR; Reference Standards

Type

Reference Standards

Related Pathways

Others; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bazedoxifene-standard.html

Smiles

CC1=C(C2=CC=C(O)C=C2)N(CC3=CC=C(OCCN4CCCCCC4)C=C3)C5=CC=C(O)C=C51

Molecular Formula

C30H34N2O3

Molecular Weight

470.60

References & Citations

[1]Barry S Komm, et al. Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity. Endocrinology. 2005 Sep;146 (9) :3999-4008.|[2]Xiaojuan Wu, et al. Bazedoxifene as a Novel GP130 Inhibitor for Pancreatic Cancer Therapy. Mol Cancer Ther. 2016 Nov; 15 (11) : 2609–2619.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Curated Selection

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