Vanillylmandelic acid-d3

Vanillylmandelic acid-d3 is the deuterium labeled Vanillylmandelic acid. Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the disorder in neurotransmitter metabolism as well. Vanillylmandelic acid has antioxidant activity towards DPPH radical with an IC50 value of 33 μM[1].

Product Specifications

CAS Number

[74495-70-8]

Product Name Alternative

Mutagenic Impurity of Tenofovir Disoproxil; Tenofovir Impurity 2,(Z)-Mutagenic Impurity of Tenofovir Disoproxil

UNSPSC

12352005

Target

Endogenous Metabolite

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Purity

99.50

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC(C(C1=CC(OC([2H])([2H])[2H])=C(C=C1)O)O)=O

Molecular Formula

C9H7D3O5

Molecular Weight

201.19

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Michalis K Kolentinis, et al.Cardiovascular effects of vanillylmandelic acid in rats. Eur J Pharmacol. 2013 Mar 5;703 (1-3) :46-52.|[3]Dušan Dimić, et al. Experimental and theoretical elucidation of structural and antioxidant properties of vanillylmandelic acid and its carboxylate anion. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Jun 5;198:61-70.