SARD279
Product Specifications
UNSPSC Description
SARD279 is a potent and selective Androgen Receptor degrader with DC50 value of 1099 nM. SARD279 can be used in prostate cancer research[1].(Structure Note: Pink: target protein ligand (HY-117486); Blue,: Hyt (HY-W001578); Black: linker (HY-W004896))
Target Antigen
Androgen Receptor; PROTACs
Type
Reference compound
Related Pathways
PROTAC;Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sard279.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OCCOCCNC(CCCN(C1(C)C)C(N(C(C=C2)=CC(C(F)(F)F)=C2C#N)C1=O)=S)=O)CC3(C[C@H](C4)C5)C[C@H]5C[C@H]4C3
Molecular Weight
662.76
References & Citations
[1]Salami J, et al. Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance. Commun Biol. 2018 Aug 2;1:100.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-164807/SARD279-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-164807/SARD279-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1489236-55-6
Available Sizes
Curated Selection
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