Human Arylsulfatase A

<strong>Human Arylsulfatase A</strong>_x000D_ <strong>Catalog number:</strong> B2012373_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 5 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> 53 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> Cerebroside-Sulfatase, ASA, Metachromatic Leucodystrophy, ARSA_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Gómez-Torres MJ, Huerta-Retamal N, Robles-Gómez L, Sáez-Espinosa P, Aizpurua J, Avilés M, Romero A. Arylsulfatase A Remodeling during Human Sperm In Vitro Capacitation Using Field Emission Scanning Electron Microscopy (FE-SEM) Cells. 2021 Jan 23;10(2):222._x000D_ 2: Pajarola S, Weißenberg C, Baysal F, Bruchelt G, Krägeloh-Mann I, Böhringer J. Measurement of recombinant human arylsulfatase A and leukocyte sulfatase activities by analytical isotachophoresis J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Aug 15;1124:109-113._x000D_ 3: Huerta-Retamal N, Sáez-Espinosa P, Robles-Gómez L, Romero A, Aizpurua J, Gómez-Torres MJ. [Localization of Arylsulfatase A during in vitro incubation of human spermatozoa in capacitation media] Rev Int Androl. 2021 Apr-Jun;19(2):129-136._x000D_ 4: Troy S, Wasilewski M, Beusmans J, Godfrey CJ. Pharmacokinetic Modeling of Intrathecally Administered Recombinant Human Arylsulfatase A (TAK-611) in Children With Metachromatic Leukodystrophy Clin Pharmacol Ther. 2020 Jun;107(6):1394-1404._x000D_ 5: Wright T, Li A, Lotterhand J, Graham AR, Huang Y, Avila N, Pan J. Nonclinical comparability studies of recombinant human arylsulfatase A addressing manufacturing process changes PLoS One. 2018 Apr 19;13(4):e0195186._x000D_ 6: Í Dali C, Sevin C, Krägeloh-Mann I, Giugliani R, Sakai N, Wu J, Wasilewski M. Safety of intrathecal delivery of recombinant human arylsulfatase A in children with metachromatic leukodystrophy: Results from a phase 1/2 clinical trial Mol Genet Metab. 2020 Sep-Oct;131(1-2):235-244._x000D_ 7: Martino S, Consiglio A, Cavalieri C, Tiribuzi R, Costanzi E, Severini GM, Emiliani C, Bordignon C, Orlacchio A. Expression and purification of a human, soluble Arylsulfatase A for Metachromatic Leukodystrophy enzyme replacement therapy J Biotechnol. 2005 May 25;117(3):243-51._x000D_ 8: Í Dali C, Groeschel S, Moldovan M, Farah MH, Krägeloh-Mann I, Wasilewski M, Li J, Barton N, Krarup C. Intravenous arylsulfatase A in metachromatic leukodystrophy: a phase 1/2 study Ann Clin Transl Neurol. 2021 Jan;8(1):66-80._x000D_ 9: Lee JS, Kanai K, Suzuki M, Kim WS, Yoo HS, Fu Y, Kim DK, Jung BC, Choi M, Oh KW, Li Y, Nakatani M, Nakazato T, Sekimoto S, Funayama M, Yoshino H, Kubo SI, Nishioka K, Sakai R, Ueyama M, Mochizuki H, Lee HJ, Sardi SP, Halliday GM, Nagai Y, Lee PH, Hattori N, Lee SJ. Arylsulfatase A, a genetic modifier of Parkinson's disease, is an α-synuclein chaperone Brain. 2019 Sep 1;142(9):2845-2859._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/28762252">10: Böhringer J, Santer R, Schumacher N, Gieseke F, Cornils K, Pechan M, Kustermann-Kuhn B, Handgretinger R, Schöls L, Harzer K, Krägeloh-Mann I, Müller I. Enzymatic characterization of novel arylsulfatase A variants using human arylsulfatase A-deficient immortalized mesenchymal stromal cells Hum Mutat. 2017 Nov;38(11):1511-1520. </a>_x000D_ _x000D_ <strong>Products Related to Human Arylsulfatase A can be found at</strong> <a href="https://moleculardepot.com/product-category/Enzymes/"> Enzymes</a>