Human Complement Standard (normal human serum)

Unlike lyophilized complement sources, QuidelOrtho complement standard maintains high levels of complement hemolytic activity and antigenic integrity. For this reason it is an ideal external standard for a variety of laboratory functional and antigenic assays for specific complement proteins (e.g., CH50, APH50, RID, C3 H50, etc.) . Sera obtained from blood banks and other large pools may not be suitable for many procedures due to high levels of background complement activation. Conversely, in house serum draws are complicated by several factors including the necessity of maintaining standardized pools of complement for ongoing experimentation and the confidentiality requirements with regard to infectious disease testing. Quidel’s Human Complement Standard has been tested for antigenic levels of C1q, C2, C3, C4, C5, C6, C7, C8, C9, Factor B, Factor H and Factor P, by Radial Immuno-Diffusion (RID) . Functional levels of the complement proteins C1q, C2, C3, C4, C5, C6, C7, C8, C9 and Factor B and Factor D have been determined by standard hemolytic assay. Classical pathway hemolytic activity (CH50) and alternative pathway hemolytic activity (AH50) have also been measured by standard techniques.