Factor B Protein
Purified human Factor B protein
Product Specifications
Background
Purified human complement Factor B. Factor B is one of the proteins unique to the Alternative Complement Pathway. The 93 kD Factor B protein is made up of a single peptide chain. When the alternative pathway is activated either directly or by the classical pathway via the amplification loop, C3b can bind whole Factor B. Factor D can then cleave Factor B in a single site to yield Ba and Bb. Bb can then become the enzymatically active constituent of the C3 and C5 alternative pathway convertases.
Source
Normal human serum
Applications
See citations and technical data sheet for application info.
Concentration
1.0 mg/mL (refer to CoA for lot specific concentration)
Purity
>90% by SDS-PAGE
Activity
>90% versus normal human serum standard.
Form
Frozen liquid. 10 mM Sodium phosphate, 145 mM NaCl, pH 7.2. No preservative, 0.22 μm filtered.
Molecular Weight
93,000 Da (single chain)
Storage Conditions
Store at -70°C or below. Avoid freeze/thaw.
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