C7 Antibody (Monoclonal)
A murine monoclonal antibody to an epitope on C7 protein.
Product Specifications
Background
Complement component C7 is a single-chain glycoprotein with a molecular weight of 95 kD. C7 protein is present in human plasma at an approximate concentration of 55 μg/ml. Upon activation of the lectin, classical or alternative pathways, C7 becomes integrated into the terminal complement complex. The Terminal Complement Complex (TCC) is a general term for both membrane-bound C5b-9, or Membrane Attack Complex (MAC), and fluid phase SC5b-9. TCC is an excellent marker for quantifying the extent of terminal pathway activation in vivo or in vitro. TCC can be deposited on the surface of transformed cells, biomaterials, as well as, a variety of other materials.
Cross Reactivity
Human, Bovine, Cat, Dog, Hamster, Horse, Rabbit, Rat.
Immunogen
Purified human protein.
Clonality
Monoclonal
Source
Mouse
Applications
See citations and technical data sheet for application info.
Concentration
1.0-1.2 mg/mL
Purity
≥ 95% by SDS PAGE
Form
Liquid. Borate Buffered Saline (pH 8.4 ± 0.2), with ≤ 0.1% Sodium Azide.
Storage Conditions
Short term (30 days) 4 ̊C. Long term at or below –20 ̊C.
Specificity
This monoclonal antibody was raised against purified human C7. It is specific for an Antigen expressed on native C7 but not expressed in MAC. It will inhibit the lysis of EA and will not detect membrane bound MAC.
Isotype
IgG1k
Conjugate
Unconjugated
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
