C6 Antibody (Monoclonal)

Complement protein, C6 is a single-chain glycoprotein with a molecular weight of 108 kD. The C6 protein is present in serum at a concentration of approximately 60 μg/ml. Upon activation of the Classical, Lectin or Alternative Complement Pathways, C6 binds to C5b and becomes integrated into the Terminal Complement Complex (TCC) . The Terminal Complement Complex (TCC) is the general term for both membrane bound C5b-9 (or Membrane Attack Complex; MAC) and fluid phase SC5b-9. Assessment of the TCC is an excellent marker for qualifying the extent of Terminal Pathway activation in vivo or in vitro. TCC can be deposited on the surface of transformed cells, biomaterials, and a variety of other surfaces.

This monoclonal antibody was raised against purified human C6. It is specific for an antigen expressed both on the native C6 molecule as well as on C6 in the MAC. It will not inhibit lysis of EA and will bind to MAC bound to a membrane.