What is the catalog number for C5 Antibody (Monoclonal)?

The catalog number for C5 Antibody (Monoclonal) is A217.

What sizes are available for C5 Antibody (Monoclonal)?

C5 Antibody (Monoclonal) is available in the following size(s): 100 µL.

Is C5 Antibody (Monoclonal) in stock?

C5 Antibody (Monoclonal) is currently made to order / not held in immediate stock. Contact us for lead time.

C5 Antibody (Monoclonal)

A murine monoclonal antibody to an epitope on C5.

Product Specifications

Background

Complement protein, C5 is unique to the Terminal Complement Pathway. The C5 protein is composed of two subunits (Alpha – 115,000 kD and Beta – 75,000 kD) and is present in serum at a concentration of approximately 70 mg/L. Under normal conditions, activation of either the Classical, Lectin or Alternative Complement Pathways generates the C5 convertase which is capable of cleaving C5 into two fragments – C5a (a potent anaphylatoxin) and C5b. Together with other proteins of the Terminal Pathway, C5b forms the Membrane Attack Complex (MAC) or Terminal Complement Complex (TCC) at the surface of a target cell; resulting in cell lysis.

Cross Reactivity

Human, Baboon

Immunogen

Purified human protein.

Clonality

Monoclonal

Source

Mouse

Applications

See citations and technical data sheet for application info.

Concentration

1.0-1.2 mg/mL

Purity

≥ 95% by SDS PAGE

Form

Liquid. Borate Buffered Saline (pH 8.4 ± 0.2), with ≤ 0.1% Sodium Azide.

Storage Conditions

Short term (30 days) 4 ̊C. Long term at or below –20 ̊C.

Specificity

This monoclonal antibody was raised against purified human C5. It is specific for an antigen expressed on the C5 but not on MAC Complex. This antibody inhibits the lysis of EA and will not bind to MAC bound to a membrane.