C4a Antibody (Polyclonal)

Under normal conditions, activation of the classical or lectin complement pathways results in the cleavage of the complement protein, C4 into C4a and C4b by the protease C1s. C4a is rapidly cleaved to its more stable, less active form C4a-des Arg by endogenous serum carboxypeptidase N enzyme. Thus, detection of C4a-des Arg provides a reliable evaluation of classical or lectin complement pathway activation.