C1q Protein
Purified human C1q protein
Product Specifications
Background
Purified human complement component C1q. Circulating C1q protein is a hexamer of three unique protein subunits (A, B, and C) with molecular weights of 29, 26 and 22 kD respectively. The assembled hexamer contains a central core or stalk, 6 collagen-like domains and 6 globular protein heads. These globular or terminal regions are responsible for the binding of immunoglobulins (IgM and IgG) . As part of the C1 complex (together with two copies each of C1r and C1s) C1q is central to activation of the classical complement pathway.
Source
Normal human serum
Applications
See citations and technical data sheet for application info.
Concentration
1.0 mg/mL (refer to CoA for lot specific concentration)
Purity
≥95% by SDS PAGE
Activity
> 1,000,000 C1H50 units/mg
Form
Frozen liquid. 10 mM HEPES, 300 mM NaCl, pH 7.2, 40% glycerol, no preservative, 0.22 μm filtered.
Molecular Weight
410,000 Da (18 chains)
Storage Conditions
Store at -70°C or below. Avoid freeze/thaw.
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