TP-060
Glucosylceramide synthase-IN-1 (T-036), a chemical probe, a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 31 nM and 51 nM for human GCS and mouse GCS, respectively. Glucosylceramide synthase-IN-1 can be used for Gaucher's disease research[1].
Product Specifications
CAS Number
2601393-20-6
Product Name Alternative
Glucosylceramide synthase-IN-1
UNSPSC
12352005
Target
Glucosylceramide Synthase (GCS)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tp-060.html
Purity
99.31
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=CC(OCC(F)(F)F)=C(C2=NC=CC3=C2CN(C4=CC=C(C(C)(O)C)C=C4)C3=O)C=C1
Molecular Formula
C24H20F4N2O3
Molecular Weight
460.42
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Recombinant Clostridium Perfringens rnhB Protein (aa 1-272) (strain SM101 / Type A)
Estrogen Related Receptor beta (ESRRB) Human Over-expression Lysate
Slc25a30 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)