TP-060
Product Specifications
UNSPSC Description
Glucosylceramide synthase-IN-1 (T-036) a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 31 nM and 51 nM for human GCS and mouse GCS, respectively. Glucosylceramide synthase-IN-1 can be used for Gaucher's disease research[1].
Target Antigen
Glucosylceramide Synthase (GCS)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tp-060.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=CC(OCC(F)(F)F)=C(C2=NC=CC3=C2CN(C4=CC=C(C(C)(O)C)C=C4)C3=O)C=C1
Molecular Weight
460.42
References & Citations
[1]Yuta Tanaka, et al. Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore. J Med Chem. 2022 Mar 10;65(5):4270-4290
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-144266/TP-060-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-144266/Glucosylceramide-synthase-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2601393-20-6
Available Sizes
Curated Selection
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