Paromomycin (sulfate)

Paromomycin (Aminosidine) sulfate, a neomycin (HY-B0470) derivative, is a broad spectrum aminoglycoside antibiotic with amebicidal and bactericidal effects. Paromomycin sulfate prematures termination of translation of mRNA and inhibits protein synthesis by specifically binds to the RNA oligonucleotide at the A site of bacterial 30S ribosomes. Paromomycin sulfate can be used for the research of bacterial and parasitic infections[1][2][3].

Product Specifications

CAS Number

[1263-89-4]

Product Name Alternative

Aminosidine (sulfate)

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Antibiotic; Bacterial; Parasite

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Paromomycin-sulfate.html

Concentration

10mM

Purity

99.96

Solubility

DMSO : < 1 mg/mL|Ethanol : < 1 mg/mL|H2O : 100 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

N[C@@H](C[C@H]1N)[C@@]([C@@H]([C@H]1O)O[C@@](O[C@H](CO)[C@H]2O[C@@]([C@@H]([C@@H](O)[C@@H]3O)N)([H])O[C@H]3CN)([H])[C@@H]2O)([H])O[C@H]([C@@H]([C@@H](O)[C@@H]4O)N)O[C@@H]4CO.O=S(O)(O)=O

Molecular Formula

C23H47N5O18S

Molecular Weight

713.71

Precautions

H315, H319, H335

References & Citations

[1]Tony J Tavares, et al. Structure of the cytosine-cytosine mismatch in the thymidylate synthase mRNA binding site and analysis of its interaction with the aminoglycoside paromomycin. RNA. 2009 May;15 (5) :911-22.|[2]Mohamed Mammeri, et al. Efficacy of chitosan, a natural polysaccharide, against Cryptosporidium parvum in vitro and in vivo in neonatal mice. Exp Parasitol. 2018 Nov;194:1-8.|[3]Ibrahim Aly, et al. Efficacy of Low and High Dose of Paromomycin Sulfate for Treatment of Cryptosporidiosis in Immunosuppressed Infected-Mice.Global Veterinaria 15 (2) : 137-143, 2015