Bufotalin

Product Specifications

CAS Number

471-95-4

Target

Ferroptosis

Applications

Apoptosis

Smiles

C[C@@]1 (CC[C@@]2 ([H]) [C@@]3 ([H]) CC[C@@]4 ([H]) [C@@]2 (CC[C@H] (O) C4) C) [C@@H] (C (C=C5) =COC5=O) [C@@H] (OC (C) =O) C[C@@]13O

Molecular Formula

C26H36O6

Additionnal Information

Bufotalin is a bufadienolide from Venenum bufonis that acts as a novel inhibitor of GPX4 and induces iron-dependent ferroptosis in non-small cell lung cancer (NSCLC) cells, significantly reducing proliferation by accelerating GPX4 degradation and increasing intracellular Fe2+.