STAT3-IN-13
Product Specifications
CAS Number
2248552-86-3
Target
STAT
Applications
Apoptosis
Smiles
N#CC1=C (SC2=C1CCN (C2) C (NC3=CC=C (C=C3) OC) =O) NC (C (C=N4) =CN4C) =O
Molecular Formula
C21H20N6O3S
Additionnal Information
STAT3-IN-13 (compound 6f) is a STAT3 inhibitor. It exhibits anti-proliferative activity and binds to the STAT3 SH2 domain with a KD of 0.46 μM. This compound inhibits STAT3 Y705 phosphorylation and downstream target gene expression. In vitro studies show STAT3-IN-13 induces apoptosis, while in vivo experiments demonstrate its ability to suppress tumor growth and metastasis. STAT3-IN-13 has potential applications in cancer research.
Storage Conditions
3 years-20°C powder 2 years-80°C in solvent
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