HGC652
Product Specifications
CAS Number
3055558-98-7
Target
Molecular Glues
Applications
Others
Smiles
CN (C (C1=CC=C (C2=C (SC) C=C (F) C=C2) C=C1S (=O) (C) =O) =O) CC3CCCCC3
Molecular Formula
C23H28FNO3S2
Additionnal Information
HGC652 functions as a molecular glue by targeting E3 ubiquitin ligase TRIM21. It facilitates the formation of a TRIM21-NUP98 ternary complex, leading to degradation of NUP155 and nuclear pore complex proteins, ultimately resulting in cell death. The compound shows inhibitory effects on the proliferation of various cancer cell lines, with activity dependent on TRIM21 expression levels.
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS1383132 Inquire
Recombinant Staphylococcus aureus Chaperone protein ClpB (clpB), partial
Sign In for Pricing
View Details 
LV705333 1.0 µg DNA
C20orf96 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
Sign In for Pricing
View Details