What is the catalog number for BMS-986260?

The catalog number for BMS-986260 is E6646-25mg.

What sizes are available for BMS-986260?

BMS-986260 is available in the following size(s): 25 mg.

Is BMS-986260 in stock?

BMS-986260 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures BMS-986260?

BMS-986260 is manufactured by Bimake.

What is the estimated delivery time for BMS-986260?

Estimated delivery time for BMS-986260 is approximately 15 business day(s), depending on your location.

BMS-986260

Product Specifications

CAS Number

2001559-19-7

Target

TGF-beta/Smad

Applications

TGF-beta/Smad

Molecular Formula

C18H12ClFN6O

Additionnal Information

BMS-986260 is an orally active immuno-oncology agent that inhibits TGFβR1 with an IC50 of 1.6 nM. It shows selectivity for TGFβR1 compared to TGFβR2 and over 200 other kinases. In MINK and NHLF cell lines, BMS-986260 blocks TGFβ-induced pSMAD2/3 nuclear translocation with IC50 values of 350 nM and 190 nM, respectively.