Auceliciclib (AU3-14, Ulecaciclib)
Product Specifications
CAS Number
2075750-05-7
Target
CDK4/6
Applications
Cell Cycle
Smiles
FC1=C (C2=C (C) N=C (NC3CCCC3) S2) N=C (NC4=NC=C (CN5CCN (CC5) CC) C=C4) N=C1
Molecular Formula
C25H33FN8S
Additionnal Information
Ulecaciclib is an orally active cyclin-dependent kinase (CDK) inhibitor with Ki values of 0.62 μM for CDK2/Cyclin A, 0.2 nM for CDK4/Cyclin D1, 3 nM for CDK6/Cyclin D3, and 0.63 μM for CDK7/Cyclin H. This compound demonstrates blood-brain barrier penetration and favorable pharmacokinetic properties.
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