BMS-986408
Product Specifications
CAS Number
2618418-12-3
Smiles
CC[C@H]1CN ([C@@H] (CN1C2=NC (N (C3=CC=C (N=C32) C#N) C) =O) CC) [C@H] (C4=CC=C (C=C4) C (F) (F) F) CC
Molecular Formula
C27H31F3N6O
Additionnal Information
BMS-986408 is a first-in-class dual inhibitor of DGKα and DGKζ, exhibiting IC50 values of 0.0003 μM and 0.002 μM for DGKα and DGKζ lipid kinase activity, respectively. It potentiates T cell–receptor signaling and T-cell activation, enhancing the effectiveness of both PD-1 and CAR T-cell therapy in preclinical models.
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
126289 50 µg
ELMO1 (Engulfment and Cell Motility Protein 1, Protein Ced-12 Homolog, KIAA0281)
Sign In for Pricing
View Details 