BMS-986408
Product Specifications
CAS Number
2618418-12-3
Smiles
CC[C@H]1CN ([C@@H] (CN1C2=NC (N (C3=CC=C (N=C32) C#N) C) =O) CC) [C@H] (C4=CC=C (C=C4) C (F) (F) F) CC
Molecular Formula
C27H31F3N6O
Additionnal Information
BMS-986408 is a first-in-class dual inhibitor of DGKα and DGKζ, exhibiting IC50 values of 0.0003 μM and 0.002 μM for DGKα and DGKζ lipid kinase activity, respectively. It potentiates T cell–receptor signaling and T-cell activation, enhancing the effectiveness of both PD-1 and CAR T-cell therapy in preclinical models.
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