HM43239
Product Specifications
CAS Number
2569527-64-4
Target
FLT3
Applications
Protein Tyrosine Kinase
Smiles
CC1CN (CC (C) N1) CC2=CC (=CC (=C2) NC3=NC=C (Cl) C (=N3) C4=C[NH]C5=C4C=CC (=C5) C) C6CC6
Molecular Formula
C29H33ClN6
Additionnal Information
HM43239 is a novel potent small molecule FLT3 inhibitor that selectively inhibits not only FLT3 wild type, ITD mutants or TKD mutations, but also FLT3 ITD/TKD double mutations. IC50s' of HM43239 against FLT3 WT, FLT3 ITD and FLT3 D835Y kinases are 1.1 nM, 1.8 nM and 1.0 nM, respectively.
Storage Conditions
3 years -20°C powder
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