Aphidicolin

Product Specifications

CAS Number

38966-21-1

Target

DNA/RNA Synthesis

Applications

Cell Cycle

Smiles

C[C@@]12[C@]34[C@] (CC[C@@]1 ([H]) [C@@] (C) ([C@H] (O) CC2) CO) ([H]) C[C@] ([C@] (CO) (O) CC4) ([H]) C3

Molecular Formula

C20H34O4

Additionnal Information

Aphidicolin is a tetracyclic diterpenoid antibiotic produced by *Cephalosporium aphidicola* that specifically inhibits eukaryotic DNA polymerases α and δ, thereby blocking DNA replication and mitotic cell division. This compound demonstrates broad antiviral activity, including inhibition of herpes simplex virus replication and anti-orthopoxvirus effects. Additionally, aphidicolin enhances arabinosyl nucleoside-induced apoptosis in HL-60 human promyelocytic leukemia cells.