Ataluren (PTC124)
Product Specifications
CAS Number
775304-57-9
Target
CFTR
Applications
Transmembrane Transporters
Smiles
C1=CC=C (C (=C1) C2=NC (=NO2) C3=CC (=CC=C3) C (=O) O) F
Molecular Formula
C15H9FN2O3
Additionnal Information
Ataluren (PTC124) selectively induces ribosomal read-through of premature but not normal termination codons, with EC50 of 0.1 μM in HEK293 cells, may provide treatment for genetic disorders caused by nonsense mutations (e.g. CF caused by CFTR nonsense mutation) . Phase 3.
Storage Conditions
2 years -80 in solvent
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