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Ensartinib dihydrochloride

Product Specifications

CAS Number

2137030-98-7

Synonyms

X-396 dihydrochloride

Target

ALK

Applications

Protein Tyrosine Kinase

Smiles

CC1CN (CC (N1) C) C (=O) C2=CC=C (C=C2) NC (=O) C3=NN=C (C (=C3) OC (C) C4=C (C=CC (=C4Cl) F) Cl) N.Cl.Cl

Molecular Formula

C26H29Cl4FN6O3

Additionnal Information

Ensartinib dihydrochloride is a potent new-generation ALK inhibitor with high activity against a broad range of known crizotinib-resistant ALK mutations and CNS metastases. It potently inhibits both wild-type ALK and ALK variants (F1174, C1156Y, L1196M, S1206R, T1151, and G1202R mutants) with in vitro IC50s of <4 nM.

Storage Conditions

3 years -20°C powder

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