Carfilzomib (PR-171)
Product Specifications
CAS Number
868540-17-4
Target
Proteasome
Applications
Proteases
Smiles
CC (C) CC (C (=O) C1 (CO1) C) NC (=O) C (CC2=CC=CC=C2) NC (=O) C (CC (C) C) NC (=O) C (CCC3=CC=CC=C3) NC (=O) CN4CCOCC4
Molecular Formula
C40H57N5O7
Additionnal Information
Carfilzomib (PR-171) is an irreversible proteasome inhibitor with IC50 of <5 nM in ANBL-6 cells, displayed preferential in vitro inhibitory potency against the ChT-L activity in the β5 subunit, but little or no effect on the PGPH and T-L activities. Carfilzomib activates prosurvival autophagy and induces cell apoptosis.
Storage Conditions
2 years -80 in solvent
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