Dabrafenib (GSK2118436)
Product Specifications
CAS Number
1195765-45-7
Synonyms
GSK2118436, GSK2118436A
Target
Raf
Applications
MAPK
Smiles
CC (C) (C) C1=NC (=C (S1) C2=NC (=NC=C2) N) C3=C (C (=CC=C3) NS (=O) (=O) C4=C (C=CC=C4F) F) F
Molecular Formula
C23H20F3N5O2S2
Additionnal Information
Dabrafenib is a mutant BRAFV600E specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf (wt) and c-Raf, respectively.
Storage Conditions
2 years -80 in solvent
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