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MK-2461

Product Specifications

CAS Number

917879-39-1

Target

C-Met

Applications

Protein Tyrosine Kinase

Smiles

CN1C=C (C=N1) C2=CC3=C (C=CC4=C (C3=O) C=C (C=C4) NS (=O) (=O) N (C) CC5COCCO5) N=C2

Molecular Formula

C24H25N5O5S

Additionnal Information

MK-2461 is a potent, multi-targeted inhibitor for c-Met (WT/mutants) with IC50 of 0.4-2.5 nM, less potent to Ron, Flt1; 8- to 30-fold greater selectivity of c-Met targets versus FGFR1, FGFR2, FGFR3, PDGFRβ, KDR, Flt3, Flt4, TrkA, and TrkB. Phase 1/2.

Storage Conditions

2 years -80 in solvent

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