Wortmannin
Product Specifications
CAS Number
19545-26-7
Synonyms
KY 12420, SL-2052, BRN 0067676, NSC 627609
Target
ATM/ATR
Applications
PI3K/Akt/mTOR
Smiles
CC (=O) OC1CC2 (C (CCC2=O) C3=C1C4 (C (OC (=O) C5=COC (=C54) C3=O) COC) C) C
Molecular Formula
C23H24O8
Additionnal Information
Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM in a cell-free assay, with little selectivity within the PI3K family. Wortmannin blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM in cell-free assays. Wortmannin also inhibits PLK1 activity.
Storage Conditions
2 years -80 in solvent
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