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Evofosfamide (TH-302)

Product Specifications

CAS Number

918633-87-1

Target

Others

Applications

Others

Smiles

CN1C (=CN=C1[N+] (=O) [O-]) COP (=O) (NCCBr) NCCBr

Molecular Formula

C9H16Br2N5O4P

Additionnal Information

Evofosfamide (TH-302) is a selective hypoxia-activated prodrug targeting hypoxic regions of solid tumors with IC50 of 19 nM, demonstrates 270-fold enhanced cytotoxicity under hypoxia versus their potency under aerobic conditions, stable to cytochrome P450 metabolism.

Storage Conditions

2 years -80 in solvent

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