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R547

Product Specifications

CAS Number

741713-40-6

Synonyms

Ro 4584820

Target

CDK

Applications

Cell Cycle

Smiles

COC1=C (C (=C (C=C1) F) F) C (=O) C2=CN=C (N=C2N) NC3CCN (CC3) S (=O) (=O) C

Molecular Formula

C18H21F2N5O4S

Additionnal Information

R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1.

Storage Conditions

2 years -80 in solvent

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