CX-5461 (Pidnarulex)
Product Specifications
CAS Number
1138549-36-6
Target
DNA/RNA Synthesis
Applications
Cell Cycle
Smiles
CC1=CN=C (C=N1) CNC (=O) C2=C3N (C4=CC=CC=C4S3) C5=C (C2=O) C=CC (=N5) N6CCCN (CC6) C
Molecular Formula
C27H27N7O2S
Additionnal Information
Pidnarulex (CX-5461) is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.
Storage Conditions
2 years -80 in solvent
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