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CCT128930

Product Specifications

CAS Number

885499-61-6

Target

Akt

Applications

PI3K/Akt/mTOR

Smiles

C1CN (CCC1 (CC2=CC=C (C=C2) Cl) N) C3=NC=NC4=C3C=CN4

Molecular Formula

C18H20ClN5

Additionnal Information

CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM in a cell-free assay, 28-fold greater selectivity for Akt2 than the closely related PKA kinase. CCT128930 induces cell cycle arrest, DNA damage, and autophagy independent of Akt inhibition. High dose of CCT128930 triggers cell apoptosis in HepG2 cells.

Storage Conditions

2 years -80 in solvent

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