Rebastinib (DCC-2036)
Product Specifications
CAS Number
1020172-07-9
Target
Bcr-Abl
Applications
Protein Tyrosine Kinase
Smiles
CC (C) (C) C1=NN (C (=C1) NC (=O) NC2=C (C=C (C=C2) OC3=CC (=NC=C3) C (=O) NC) F) C4=CC5=C (C=C4) N=CC=C5
Molecular Formula
C30H28FN7O3
Additionnal Information
Rebastinib (DCC-2036) is a conformational control Bcr-Abl inhibitor for Abl1 (WT) and Abl1 (T315I) with IC50 of 0.8 nM and 4 nM, also inhibits SRC, LYN, FGR, HCK, KDR, FLT3, and Tie-2, and low activity to seen towards c-Kit. Phase 1.
Storage Conditions
2 years -80 in solvent
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