Buparlisib (BKM120)
Product Specifications
CAS Number
944396-07-0
Synonyms
NVP-BKM120
Target
PI3K
Applications
PI3K/Akt/mTOR
Smiles
C1COCCN1C2=NC (=NC (=C2) C3=CN=C (C=C3C (F) (F) F) N) N4CCOCC4
Molecular Formula
C18H21F3N6O2
Additionnal Information
Buparlisib (BKM120, NVP-BKM120) is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM in cell-free assays, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ. Buparlisib induces apoptosis. Phase 2.
Storage Conditions
2 years -80 in solvent
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