Allitinib tosylate
Product Specifications
CAS Number
1050500-29-2
Synonyms
AST-1306 TsOH, AST-6
Target
EGFR
Applications
Protein Tyrosine Kinase
Smiles
CC1=CC=C (C=C1) S (=O) (=O) O.C=CC (=O) NC1=CC2=C (C=C1) N=CN=C2NC3=CC (=C (C=C3) OCC4=CC (=CC=C4) F) Cl
Molecular Formula
C24H18ClFN4O2, C7H8O3S
Additionnal Information
Allitinib tosylate (AST-1306 TsOH, AST-6) is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases.
Storage Conditions
2 years -80 in solvent
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