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Licofelone (ML3000)

Product Specifications

CAS Number

156897-06-2

Target

COX

Applications

Neuronal Signaling

Smiles

CC1 (CC2=C (C (=C (N2C1) CC (=O) O) C3=CC=C (C=C3) Cl) C4=CC=CC=C4) C

Molecular Formula

C23H22ClNO2

Additionnal Information

Licofelone (ML3000, Compound 3e) is a dual inhibitor of COX and 5-lipoxygenase (5-LOX) with IC50 of 0.21 μM and 0.18 μM, respectively. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins. Licofelone is considered as a treatment for osteoarthritis.

Storage Conditions

2 years -80 in solvent

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