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Semagacestat (LY450139)

Product Specifications

CAS Number

425386-60-3

Target

Secretase

Applications

Stem Cells & Wnt

Smiles

CC (C) C (C (=O) NC (C) C (=O) NC1C2=CC=CC=C2CCN (C1=O) C) O

Molecular Formula

C19H27N3O4

Additionnal Information

Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, also inhibits Notch signaling with IC50 of 14.1 nM in H4 human glioma cell. Phase 3.

Storage Conditions

2 years -80 in solvent

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