Bumetanide
Product Specifications
CAS Number
28395-03-1
Synonyms
Ro 10-6338, PF 1593
Target
NKCC
Applications
Transmembrane Transporters
Smiles
CCCCNC1=C (C (=CC (=C1) C (=O) O) S (=O) (=O) N) OC2=CC=CC=C2
Molecular Formula
C17H20N2O5S
Additionnal Information
Bumetanide is a loop diuretic of the sulfamyl category to treat heart failure. Bumetanide is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively.
Storage Conditions
2 years -80 in solvent
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