Avagacestat (BMS-708163)
Product Specifications
CAS Number
1146699-66-2
Target
Beta Amyloid
Applications
Neuronal Signaling
Smiles
C1=CC (=CC=C1S (=O) (=O) N (CC2=C (C=C (C=C2) C3=NOC=N3) F) C (CCC (F) (F) F) C (=O) N) Cl
Molecular Formula
C20H17ClF4N4O4S
Additionnal Information
Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.
Storage Conditions
2 years -80 in solvent
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