JNJ-7706621

Product Specifications

CAS Number

443797-96-4

Target

Aurora Kinase

Applications

Cell Cycle

Smiles

C1=CC (=C (C (=C1) F) C (=O) N2C (=NC (=N2) NC3=CC=C (C=C3) S (=O) (=O) N) N) F

Molecular Formula

C15H12F2N6O3S

Additionnal Information

JNJ-7706621 is a pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1.

Storage Conditions

2 years -80 in solvent

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