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Aprepitant

Product Specifications

CAS Number

170729-80-3

Synonyms

MK-0869, L-754030

Target

HIV

Applications

Microbiology

Smiles

CC (C1=CC (=CC (=C1) C (F) (F) F) C (F) (F) F) OC2C (N (CCO2) CC3=NNC (=O) N3) C4=CC=C (C=C4) F

Molecular Formula

C23H21F7N4O3

Additionnal Information

Aprepitant is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM. Aprepitant reduces levels of pro-inflammatory cytokines including G-CSF, IL-6, IL-8 and TNFα. Aprepitant inhibits HIV infection of human macrophages.

Storage Conditions

2 years -80 in solvent

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