Sepantronium Bromide (YM155)
Product Specifications
CAS Number
781661-94-7
Target
Survivin
Applications
Apoptosis
Smiles
CC1=[N+] (C2=C (N1CCOC) C (=O) C3=CC=CC=C3C2=O) CC4=NC=CN=C4.[Br-]
Molecular Formula
C20H19BrN4O3
Additionnal Information
Sepantronium Bromide (YM155) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM in HeLa-SURP-luc and CHO-SV40-luc cells; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells. Phase 2.
Storage Conditions
2 years -80 in solvent
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