BI 2536
Product Specifications
CAS Number
755038-02-9
Target
PLK
Applications
Cell Cycle
Smiles
CCC1C (=O) N (C2=CN=C (N=C2N1C3CCCC3) NC4=C (C=C (C=C4) C (=O) NC5CCN (CC5) C) OC) C
Molecular Formula
C28H39N7O3
Additionnal Information
BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. Phase 2.
Storage Conditions
2 years -80 in solvent
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