ZM 447439
Product Specifications
CAS Number
331771-20-1
Target
Aurora Kinase
Applications
Cell Cycle
Smiles
COC1=C (C=C2C (=C1) C (=NC=N2) NC3=CC=C (C=C3) NC (=O) C4=CC=CC=C4) OCCCN5CCOCC5
Molecular Formula
C29H31N5O4
Additionnal Information
ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc.
Storage Conditions
2 years -80 in solvent
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