Motesanib Diphosphate (AMG-706)
Product Specifications
CAS Number
857876-30-3
Target
VEGFR
Applications
Protein Tyrosine Kinase
Smiles
CC1 (CNC2=C1C=CC (=C2) NC (=O) C3=C (N=CC=C3) NCC4=CC=NC=C4) C.OP (=O) (O) O.OP (=O) (O) O
Molecular Formula
C22H23N5O.2H3PO4
Additionnal Information
Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 2 nM/3 nM/6 nM, respectively; similar activity against Kit (c-Kit), ~10-fold more selective for VEGFR than PDGFR and Ret. Phase 3.
Storage Conditions
2 years -80 in solvent
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